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KMID : 0378119900170020383
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Chungnam Medical Journal
1990 Volume.17 No. 2 p.383 ~ p.391
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Cell-Mediated Immunity in Patients with Lung Cancer
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Abstract
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Cell-mediated immunity (CMI) was evaluated in 30 patients with lung cancer by in vivo and in vitro methods. These included skin test with CMI multitest kit, determination of peripheral T lymphocytes, and lymphocyte response to phytohemagglutinin (PHA) and concanavalin A (Con A). The positive scores of skin test were significantly lower in lung cancer group than controls (p<0.05), and there were no significant differences in T cell subsets. The response to PHA and Con A were greatly depressed in lung cancer and it was more apparent in advanced stage. But there was no difference in stimulation index (SI) between cancer patients and normal controls. The cumulative index (CI) was more significant difference in cancer patients and advanced stage.
These results suggest that depressed CMI in patients with lung cancer might be caused by lymphocytic dysfunction and cumulative index is more accurate to describe lymphocyte blastogenic function than stimulation index.
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KEYWORD
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